5-Amino-1MQ guide

At a glance

What the research says

NNMT methylates nicotinamide and is found at higher levels in adipose tissue and skeletal muscle in some metabolic conditions. A 2018 mouse study examined a series of methylquinolinium NNMT inhibitors for membrane permeability, selectivity and effects in cultured fat cells. The inhibitors lowered the reaction product 1-methylnicotinamide and raised intracellular NAD+ in those cells.[3]

In the same work, diet-induced obese mice given a potent inhibitor from the series lost body weight and adipose mass compared with controls while remaining on a high-fat diet. These are animal endpoints measured under laboratory feeding conditions. The paper does not report a human exposure, and its injection route in mice differs from the oral route the library uses.[3]

A separate 2021 study validated an assay for 5-Amino-1MQ in rat plasma and urine and applied it to intravenous and oral dosing in rats. It reports a mean terminal half-life of about 3.8 hours after intravenous dosing and 6.9 hours after oral dosing, with oral bioavailability of about 38.4%. Those rat values are the basis of the library's oral model.[2][1]

Cited amounts

The library lists no package amount, capsule strength or vial for 5-Amino-1MQ, and neither cited study reports a human amount. This guide therefore gives no milligram figure for people. An oral entry in a tracker is recorded in the milligrams printed on whatever product label the user holds.[1][2]

Half-life and timing

With 6.9 hours per halving, 50% remains at 6.9 hours and about 3.1% at 34.5 hours. Across a 24 hour day the model leaves roughly 9% of a single contribution. The study also mentions possible enterohepatic recirculation, which a one-compartment decay line does not represent. The curve is an oral rat parameter drawn on a human calendar, so it shows arithmetic structure rather than an expected human profile.[1][5]

Reconstitution

5-Amino-1MQ is logged as an oral entry, so there is no powder, no added water and no syringe-unit step. The arithmetic is a product of label strength and count: milligrams per capsule multiplied by the number taken gives the milligram entry. Because no sourced product strength exists in the library, this guide leaves that strength as a variable rather than inventing one.[1]

Tracking it in PinPoint

Frequently asked questions

Is the 5-Amino-1MQ half-life a human number?

No. The 6.9 hour value is the oral apparent half-life measured in rats. The library uses it because it models the oral route, and labels the entry as preclinical. The shorter 3.8 hour value from the same study belongs to intravenous dosing in rats.[1][2]

Why does the 5-Amino-1MQ guide link to the general calculator?

The calculator converts powder vials into concentration and syringe units. An oral capsule entry has no reconstitution step, so no compound-specific calculator route is generated for it. The general calculator remains available for injectable compounds logged alongside it.[1][5]

Which 5 amino 1mq study measured oral bioavailability?

The 2021 rat pharmacokinetics study compared intravenous and oral dosing and reported oral bioavailability of about 38.4%. It is the only source in the library for that figure, and it concerns rats rather than people.[2][1]

Can a peptide tracker app record 5-Amino-1MQ?

PinPoint's compound library includes 5-Amino-1MQ. The app description covers logging compound, dose, site, and pain level, as well as viewing modeled levels between recorded doses. The curve uses published reference inputs and does not account for individual variation. The tracker records the schedule entered by its user; it does not choose a dose or recommend a schedule change.[1][4]

Sources

Facts and reference links were retrieved from the PinPoint application library on 5 October 2026. Links below preserve the library's citations; a catalog source supports a package amount only. Source references carried from the library have not all been independently reverified. Arithmetic examples are identified separately from clinical evidence.

1. PinPoint compound library, 5-Amino-1MQSnapshot of the application library; its references and uncertainty are retained below.Retrieved 2026-10-05 · library
2. PubMed rat pharmacokinetics study 34304009Published 2021 in a pharmaceutical and biomedical analysis journal. Oral and intravenous half-life and oral bioavailability checked against the abstract on 5 October 2026.Retrieved 2026-10-05 · library-reference
3. PubMed mouse obesity study 29155147Published 2018 in a biochemical pharmacology journal. Methylquinolinium NNMT inhibitor series in cultured adipocytes and diet-induced obese mice; checked against the abstract on 5 October 2026.Retrieved 2026-10-05 · primary-reference
4. PinPoint App Store descriptionFeature wording from the approved application description, not pricing.Retrieved 2026-10-05 · app-description
5. Unit conversion and exponential-decay arithmeticC = amount / volume; remaining fraction = 2^(-elapsed / half-life). These are illustrations, not measurements.Retrieved 2026-10-05 · arithmetic