What is the difference between CJC-1295 with DAC and no DAC?
Both are analogues of the first 29 amino acids of growth-hormone-releasing hormone. DAC stands for drug affinity complex, a reactive chemical group that lets the peptide attach to circulating albumin [2]. An FDA evaluation document identifies the two forms, with and without that group, as distinct substances [1]. PinPoint's library keeps them as separate entries, both labeled limited human research [4].
Searches for cjc-1295 dac and cjc-1295 no dac are really asking which one a vial contains and why the frequencies attached to them differ by an order of magnitude. The answer is the half-life, and the half-life is a direct consequence of the albumin binding.
What do studies report for each form?
A 2005 rat study showed that GRF(1-29) conjugated to albumin through this chemistry still activated the growth-hormone-releasing receptor on the pituitary, and identified CJC-1295 as the lead compound [2]. Albumin binding is what extends its time in circulation.
A 2006 study in healthy adults gave CJC-1295 with DAC by subcutaneous injection in single ascending amounts and in two or three weekly or every-other-week injections [3]. After a single injection, mean growth hormone rose two- to tenfold for six days or more and IGF-I rose 1.5- to threefold for 9 to 11 days. The estimated half-life was 5.8 to 8.1 days, and the authors described the 30 and 60 microgram per kilogram groups as relatively well tolerated [3].
The form without DAC has no comparable human pharmacokinetic study in the library. Its 30-minute input is a low-confidence tracking estimate, while the with-DAC entry uses 192 hours, eight days, from the upper part of the published range [4].
| Compound | Status | Half-life input | Package example |
|---|---|---|---|
| CJC-1295 (with DAC) | Limited human research | 192 h | 2 mg (vendor listing) |
| CJC-1295 (no DAC) | Limited human research, estimated model data | 0.5 h | 5 mg (vendor listing) |
How are CJC-1295 DAC and no-DAC vials measured and converted?
The library's package examples differ: 2 mg for the DAC form and 5 mg for the form without DAC [4]. In a hypothetical 2 mL, that is 1 mg/mL and 2.5 mg/mL. Each U-100 unit then holds 10 mcg of the DAC form or 25 mcg of the form without DAC, so the same 10-unit mark is 100 mcg of one and 250 mcg of the other [5].
The study amounts were set per kilogram of body weight, which is a different unit again; converting them requires a weight and is not done on this page. Timing arithmetic shows the larger difference: after 24 hours the no-DAC model holds essentially nothing of one contribution, while the DAC model still holds about 92% [5]. The CJC-1295 with DAC dosing chart, no-DAC dosing chart and the two half-life pages repeat this arithmetic.
How do people log CJC-1295 with or without DAC in PinPoint?
Choosing the right library entry is the main step, because the two share a name and differ in half-life by a factor of almost 400 [4]. Each vial is set up with its own size and water volume, and entries record compound, dose, site and pain level [6].
Schedules can be daily, twice weekly, weekly or custom, with reminders at the chosen time [6]. On the Home curve, a DAC entry overlaps the next one across days while a no-DAC entry fades within hours. Both lines are mathematical visualizations of published or estimated averages and do not account for individual variation [6]. Backfilling past entries keeps the overlap visible from the first recorded injection rather than from the day the app was installed.
Get PinPoint on the App StoreWhat do people ask about CJC-1295 with and without DAC?
- What does DAC mean in CJC-1295?
- DAC stands for drug affinity complex, a chemical group that lets the peptide bind albumin in the blood. That binding is what lengthens the half-life of the DAC form.
- What is the half-life of CJC-1295 with DAC?
- A 2006 study in healthy adults estimated 5.8 to 8.1 days. The library uses 192 hours, which is eight days, as its model input.
- What is the half-life of CJC-1295 no DAC?
- The library uses 30 minutes as a low-confidence tracking estimate. No human pharmacokinetic study of the no-DAC form appears in the library's sources.
- Are CJC-1295 DAC and no DAC interchangeable in a log?
- No. They are separate library entries with different half-life inputs and package examples. Logging one as the other would distort both the totals and the modeled curve.
- Which CJC-1295 form has a human study?
- The 2006 study in healthy adults tested the form with DAC, reporting raised growth hormone for six days or more and a half-life of 5.8 to 8.1 days. The library cites no comparable human study of the form without DAC.
Where do these facts come from?
Sources are listed by kind: labels first, then peer-reviewed papers, then PinPoint's own library, arithmetic and app description. Library values were retrieved from the PinPoint application on 5 October 2026; vendor listings support package sizes only.
- FDA evaluation document for CJC-1295FDA document identifying CJC-1295 forms with and without the drug affinity complex.Retrieved 2026-10-05 · regulatory-review
- GRF(1-29) albumin bioconjugates in rats, 2005Endocrinology, 2005. Drug affinity complex chemistry and albumin binding.Retrieved 2026-10-05 · study
- Prolonged GH and IGF-I secretion after CJC-1295 in healthy adults, 2006J Clin Endocrinol Metab, 2006. Single and multiple subcutaneous doses; half-life of several days.Retrieved 2026-10-05 · study
- PinPoint compound library, application recordsHalf-life inputs, routes, frequencies, package examples and confidence labels as stored in the iOS app library and mirrored in the peptide guides.Retrieved 2026-10-05 · library
- Unit conversion arithmeticConcentration = amount / volume; volume = amount / concentration; U-100 units = mL x 100; remaining fraction = 2^(-elapsed / half-life).Retrieved 2026-10-05 · arithmetic
- PinPoint App Store descriptionFeature wording from the approved application description, not pricing.Retrieved 2026-10-05 · app-description